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Dr. Charles Conway (Washington University School of Medicine, St. Louis) joins the podcast to discuss the RECOVER trial, a RCT that looked at vagus nerve stimulation and its effects on profoundly treatment resistant depression. Following that, AJP Editor-in-Chief Dr. Ned Kalin is joined by the October issue guest editor, Dr. William McDonald (Emory University, Atlanta) to discuss the rest of the October issue, which focuses on neuromodulation and precision therapeutics. 00:42 Conway interview 02:34 Quality of life 05:13 Ethical considerations of a sham arm in this population 07:00 Timing and VNS treatment 08:03 Clinical implications 09:02 Limitations 10:12 Further research 11:30 McDonald and Kalin interview 13:50 Song et al. 14:08 Li et al. 15:44 Donnery et al. 16:38 Valiengo et al. 17:28 Rush 20:03 Mahmoudi 22:37 Conway et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to…

Dr. Heon-Jeong Lee (Korea University, Seoul) joins AJP Audio to discuss an app-based intervention designed to help individuals with mood disorders regulate their circadian rhythms to prevent recurrence of mood episodes. Afterwards, Dr. Ned Kalin will join us again to discuss the rest of the September issue of the Journal, which takes a close look at clinical treatment. 00:44 Findings 01:42 How the app works 03:05 Differences between the app and traditional lifestyle advice 04:14 Ethics surrounding shame treatment arms 05:43 Broader applicability of the intervention 06:50 Limitations 08:19 Immediate clinical implications 09:33 Further research 10:08 Kalin interview 10:27 Yeom et al. 16:02 Schacht et al. 20:31 Khosravani et al. 24:52 Peterson et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric…

Dr. Deepak Cyril D'Souza (Yale University School of Medicine) joins the podcast to discuss a study looking at two cohorts of patients hospitalized with first instances of psychosis, one with cannabis exposure and one without. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin takes us through the August issue of the Journal, which takes a look at issues surrounding schizophrenia spectrum disorder, from the clinical to basic science. 00:40 D'Souza interview 02:38 Subtyping and schizophrenia spectrum disorder 04:19 Relapse and long-term implications for cannabis induced psychosis 05:43 Improvements in cognition 08:03 Differences between the groups 09:26 Greater access and greater potency of cannabis products 11:29 Further research 13:45 Kalin interview 13:59 D'Souza et al. 21:34 Forsyth et al. 27:36 Enwright et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here.…

Dr. Dilip Jeste (Social Determinants of Health Network, La Jolla, CA) joins the podcast to discuss how social determinants of health interact with treatment for psychiatric disorders. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin once again puts the rest of the July issue into context. 00:31 Impacts of social determinants of health on psychiatric disorders, research, and clinical care 04:43 Health related social needs versus social determinants of health 08:47 Loneliness as a risk factor 12:36 A clinician's role in societal factors 14:47 Mechanistic understandings social determinants and the exposome 18:17 Further research 22:25 Kalin interview 22:30 Jeste and Gyan 23:33 Blundell et al. 28:03 Yang et al. 32:20 Van der Meer et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse…

Dr. Jason Tucciarone and Dr. Alan Schatzberg (Stanford University, Stanford, CA) join AJP Audio to discuss the use of low-dose buprenorphine as an adjunctive therapy to extend the anti-suicidal effects of ketamine treatment in patients with major depressive disorder and suicidal ideation. AJP Editor-in-Chief Dr. Ned Kalin joins to discuss the rest of the June issue of the Journal, which takes a close look at issues surrounding suicide and severe depression. 01:20 Tucciarone and Schatzberg interview 03:36 Disparity between effects on suicidal ideation and antidepressant ratings 05:36 Ethics of placebo and ketamine in patients with suicidal ideation 08:28 Immediate clinical implications 11:40 Limitations 14:10 Further research 16:19 Kalin interview 16:24 Tucciarone et al. 20:39 Rovers et al. 24:30 Jelen et al. Transcript Board-certified psychiatrists, if you're seeking meaningful inpatient work with real clinical autonomy, consider becoming the Clinical Director for a 16-bed behavioral health hospital in…

In this special episode of AJP Audio, AJP Editor-in-Chief Dr. Ned Kalin is joined by Dr. María Oquendo (Perelman School of Medicine at the University of Pennsylvania, Philadelphia), chair of APA's Future DSM Strategic Committee to discuss a series of commentaries published in the May issue of the Journal discussing the strategic vision for the future of DSM. 00:39 Oquendo interview 03:07 Size of the response 04:18 Feedback 06:04 Incorporating the feedback 07:57 Emphasizing science with a title change for DSM 10:18 A living document 12:35 Changes from previous versions of DSM 16:08 Changes in documentation and coding 18:51 Lived experience 20:02 Working with AJP Links to the commentaries: Initial Strategy for the Future of DSMMaría A. Oquendo, M.D., Ph.D., et al. The Future of DSM: A Report From the Structure and Dimensions SubcommitteeDost Öngür, M.D., Ph.D., et al. The Future of DSM: Are Functioning and Quality of Life Essential Elements of a Complete Psychiatric Diagnosis?Karen Drexler, M.D., et al. The…

Dr. Eduardo Butelman (Icahn School of Medicine at Mount Sinai, New York) joins AJP Audio to discuss the varying incidence of psychiatric comorbidities across patients diagnosed with substance use disorders. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin joins the podcast to discuss the rest of the May issue, which includes a discussion on the future of the DSM. 00:53 Butelman interview 02:23 Mechanisms of difference between males and females 04:04 Patterns of response between males and females in substance use disorders 05:54 Implications for research into sex-based differences 07:33 Racial and ethnic variations in findings 09:30 Limitations 10:46 Immediate clinical implications? 12:09 Further research 13:18 Kalin interview 13:38 Butelman et al. 17:11 Hinojosa et al. 22:49 van Rooij et al. 26:06 The future of DSM Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast…

Yang Lu, M.S., and Catharine E. Fairbairn, Ph.D. (University of Illinois, Urbana-Champaign) join AJP Audio to discuss the longitudinal effects of the use of personal alcohol breathalyzers in a natural setting on alcohol usage. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin joins the podcast to discuss the rest of the April issue, which focuses on subjects related to substance use disorders. 00:57 What did you discover about the long term effects of using a personal blood alcohol monitor? 03:12 Do health monitoring devices actually change behaviors? 04:10 What did your cohort look like? 08:49 Disparate impact of monitoring on heavy drinkers and light drinkers 11:36 Clinical implications 14:34 Limitations 15:46 Avenues for further research 18:39 Kalin interview 18:46 Lu et al. 24:00 Wittekind et al. 29:50 Nicholson et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the…

Chelsea Dyan Gober Dykan, M.A. (Tel Aviv University, Israel), joins AJP Audio to discuss a study looking at two versions of attention bias modification with an eye towards a prophylactic impact on developing PTSD in a cohort of combat-bound soldiers. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin joins the podcast to put the rest of the March issue into context. 00:57 Attention bias modifications 03:54 Response-time and gaze-contingent paradigms 05:05 Differences in efficacy between the two arms 08:06 Ethical considerations in investigating combat-bound soldiers 10:44 Controlling for combat experiences in studying PTSD 12:24 Duration of the effect 13:44 Limitations 15:03 Immediate clinical implications 16:22 Further research 17:05 Kalin interview 17:22 Dykan et al. 21:03 Kaul et al. 26:19 Kantrowitz et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here.…

Dr. Ian Kelleher (University of Edinburgh, Scotland) joins AJP Audio to discuss an emulated target trial looking at the prophylactic qualities of doxycycline, an antibiotic, in an adolescent population at risk to develop schizophrenia spectrum disorder. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin joins the podcast to put the rest of the issue into context. 00:53 Doxycycline and the risk of developing schizophrenia 04:03 Emulated target trials versus randomized control trials 06:43 Methods of action 09:24 Dosage and exposure levels for doxycycline 10:15 Immediate clinical applications 10:56 Limitations of the study 11:33 Future research 12:43 Kalin interview 13:00 Lång et al. 19:43 Zhao et al. 25:20 Metrik et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles…

This special episode of AJP Audio brings together the editors of the American Journal Psychiatry and the AJP Residents' Journal to discuss important and impactful articles published in 2025. 00:39 Ned H. Kalin, M.D., discusses "Transcriptomic Analysis of the Human Habenula in Schizophrenia" by Ege A. Yalcinbas, Ph.D., et al. 06:23 Elisabeth Binder, M.D., Ph.D., discusses "Copy Number Variant Architecture of Child Psychopathology and Cognitive Development in the ABCD Study" by Zhiqiang Sha, Ph.D., et al. 11:17 Kathleen T. Brady, M.D., Ph.D., discusses "High-Potency Cannabis Use and Health: A Systematic Review of Observational and Experimental Studies" by Stephanie Lake, Ph.D., et al. 15:35 David A. Lewis, M.D., discusses "20 Years of Aberrant Salience in Psychosis: What Have We Learned?" by Philip R. Corlett, Ph.D., and Kurt M. Fraser, Ph.D. 17:27 William M. McDonald, M.D., discusses "Psychedelics for the Treatment of Psychiatric Disorders: Interpreting and Translating Available Evidence and Guidance for…

Dr. Julia Linke (University of Mainz, Germany) joins AJP Audio to discuss the use of neural efficiency, a measure of brain activity, as a potential biomarker in the treatment of children with anxiety disorder. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin joins the podcast to put the rest of the issue into context. 00:31 Linke interview 02:15 State or a trait? 04:15 Neural efficiency and CBT 05:22 Potential as a biomarker 07:08 Patient-rated and parent-rated measures of anxiety 08:16 Immediate clinical implications 09:50 Limitations 10:43 Future directions of research 11:44 Kalin interview 11:50 Linke et al. 15:16 Mallard et al. 18:11 Naples et al. 21:44 Mac Giollabhui et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work.…

Dr. Suresh Durgam (Intra-Cellular Therapies, a Johnson & Johnson Company, Bedminster, NJ) joins AJP Audio to discuss a phase 3 randomized controlled trial looking at the use of the antipsychotic medication lumateperone as adjunctive to antidepressant therapy in the treatment of patients with major depressive disorder. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the December issue of the Journal. 00:48 Durgam interview 03:09 Mechanism of action 04:44 Patient-reported outcomes 06:31 Immediate clinical implications 07:32 Limitations 08:08 Further research 09:25 Kalin interview 09:38 Durgam et al. 13:09 Lin et al. 17:22 Brodsky et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of…

Dr. Lara Coughlin (University of Michigan, Ann Arbor) joins AJP Audio to discuss a study looking the impact of contingency management on all cause mortality in patients with stimulant use disorder. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the November issue of the Journal. 01:09 Coughlin interview 02:05 Stimulant use disorder and contingency management 04:37 Mortality 05:12 Contingency management and "moral hazard" 08:30 Clinical uptake of contingency management 09:28 Broader applicability to psychiatric conditions 10:31 Limitations 11:39 Further research 12:32 Kalin interview 12:49 Coughlin et al. 16:41 Yalcinbas et al. 22:22 Na et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the…

This month, Deputy Editor Susan K. Schultz, M.D., discusses the association of hypnotic medications and suicide, neurometabolic disorders in treatment-refractory depression, diminished attention to eyes in autism, increased activity or energy as a primary criterion for diagnosis of bipolar mania, an instrument for diagnosing premenstrual dysphoric disorder, and how to differentiate the effects of deep brain stimulation in Parkinson's disease from the effects of the disease itself and psychiatric issues. Articles may be viewed online at ajp.psychiatryonline.org.

This month, Deputy Editor Susan K. Schultz, M.D., discusses combat attachment behaviors in former service members with PTSD, postpartum psychosis, the association between pain and opioid use disorder, work productivity in relation to depression outcome, neural response to rewards as a predictor of depression, and adjustment disorder following trauma exposure. Articles may be viewed online at ajp.psychiatryonline.org.

This month, Deputy Editor Susan K. Schultz, M.D., discusses practice and policies on perinatal substance abuse, relapse risk in patients with remitted depression, right unilateral ultrabrief-pulse ECT combined with medication in acute and maintenance geriatric depression, suicide risk calculated prospectively in a population cohort, and a new approach to fear and anxiety that takes into account both behavioral responses and conscious feeling states. Articles may be viewed online at ajp.psychiatryonline.org.

This month, Deputy Editor Susan K. Schultz, M.D., discusses research on preventing firearm suicide, treatment guidelines for adult attention deficit hyperactivity disorder, long-term effects of supported employment for people with psychiatric disabilities, predicting psychosis risk in individuals with prodromal symptoms, how often psychotic experiences precede mental disorders and vice versa, and a 30-year follow-up study of offspring of depressed parents. Articles may be viewed online at ajp.psychiatryonline.org.

This month, Deputy Editor Susan K. Schultz, M.D., discusses the diagnosis and treatment of trichotillomania, combining antidepressants with antipsychotics in schizophrenia, outcomes of the FDA reduction in the citalopram maximum dosage, heritable and nonheritable pathways to early callous and unemotional behaviors, and the effect of marriage on the risk for alcohol use disorder. Articles may be viewed online at ajp.psychiatryonline.org.

This month, Deputy Editor Susan K. Schultz, M.D., discusses accelerometers in diagnosis and treatment of late-life depression, concomitant use of SSRIs and statins, treatment of cognitive impairment in schizophrenia with an alpha-7 nicotinic receptor agonist, the relation of adolescent marijuana use to subclinical psychotic symptoms and to mortality at age 60, and the effect of nicotine exposure during pregnancy to development of schizophrenia in offspring. Articles may be viewed online at ajp.psychiatryonline.org.

This month, Deputy Editor Susan K. Schultz, M.D., discusses how psychiatrists can extend their role to treatment of general health conditions, how to evaluate randomized clinical trials, interpersonal psychotherapy for mental health problems, fluidity of symptoms in borderline personality disorder, predictors of bipolar illness in offspring of bipolar parents, and the relation of prenatal maternal distress to fetal behavior and to DNA changes in glucocorticoid-related genes in the placenta. Articles may be viewed online at ajp.psychiatryonline.org.

This month, Executive Editor Michael Roy discusses nutrient-based treatments as adjuncts to antidepressants, the prevalence and characteristics of cannabis use disorder as defined in DSM-5, long-term mortality rates in women with severe postpartum psychiatric disorders, a program for children in foster care and their biological parents designed to prevent repetition of childhood maltreatment, whether the relationship between preschool poverty and school-age depression is mediated by functional brain connectivity, and the NIMH Research Domain Criteria project. Articles may be viewed online at ajp.psychiatryonline.org.

This month, Executive Editor Michael Roy discusses a generalist model for treatment of borderline personality disorder, citalopram treatment for agitated patients with Alzheimer's dementia, buprenorphine for severe suicidal ideation and as an adjunctive treatment in cases of antidepressant nonresponse, effects of prenatal choline supplementation on early-childhood behavior problems, and mechanisms of executive system dysfunction across psychiatric disorders in youths. Articles may be viewed online at ajp.psychiatryonline.org.

This month, Deputy Editor Susan K. Schultz, M.D., discusses lurasidone for major depression with mixed features, bitemporal ECT compared with high-dose unilateral ECT given twice a week, neurocircuitry of depression with increased versus decreased appetite, attenuated psychosis syndrome, identification of distinct psychosis biotypes, and comprehensive community care for first-episode psychosis. Articles may be viewed online at ajp.psychiatryonline.org.

This month, Deputy Editor Susan K. Schultz, M.D., discusses depression following stroke; cerebral abnormalities in patients with first-episode schizophrenia; risks of poorly monitored ketamine use for depression; long-term outcomes of light therapy versus CBT for seasonal affective disorder; the reproductive safety of second-generation antipsychotics; and the effects of antipsychotic review and nonpharmacological interventions on antipsychotic use, symptoms, and mortality in nursing home residents. Articles may be viewed online at ajp.psychiatryonline.org.

This month, Executive Editor Michael Roy discusses the risk of postpartum relapse in bipolar disorder and postpartum psychosis, the relation of pregnant women's defense mechanisms to later behavior in their toddlers, sequential integration of pharmacotherapy and psychotherapy for depression, the dose-response relationship of SSRIs, the effectiveness of clozapine versus standard antipsychotic treatment for schizophrenia, and the relation of prenatal maternal depression, SSRIs, and benzodiazepines to infant neurobehavioral functioning. Articles may be viewed online at ajp.psychiatryonline.org.

This month, Deputy Editor Susan K. Schultz, M.D., discusses a request for abortion by a woman with major depression and psychosis, an update on prescription opioid abuse, and a consideration of questions about MRI findings of neuropathology underlying psychiatric illness. There also is discussion of predicting response to antipsychotic drugs from baseline striatal functional connectivity, the association between obesity and ADHD, and amygdala hyperactivity during autobiographical recall as a possible trait marker of depression. Articles may be viewed online at ajp.psychiatryonline.org.

This month, Deputy Editor Susan K. Schultz, M.D., discusses management of alcohol use disorder in patients requiring liver transplant, adding ziprasidone to escitalopram for treatment of depression, attention training for reducing PTSD symptoms, extended-release guanfacine for hyperactivity in autism spectrum disorder, a program for preventing anxiety disorders in offspring of anxious parents, and pregnancy complications following prenatal exposure to SSRIs or maternal psychiatric disorders. Articles may be viewed online at ajp.psychiatryonline.org.

This month, Deputy Editor Susan K. Schultz, M.D., discusses psychiatric symptoms in Wilson's disease, interactions between inflammation and depression, circulating miRNA levels in schizophrenia, the relation of smoking status to later schizophrenia, development of posttraumatic stress disorder in Army servicemembers following traumatic brain injury, and working in the Amish culture. Articles may be viewed online at ajp.psychiatryonline.org.

This audio program explores the role of ketamine and other NMDA antagonists as treatments for depression, and a replication study of a gene-environment interaction affecting depression risk. A study lasting four decades looked at whether ADHD in adults is a childhood-onset disorder, and another longitudinal study followed up adolescents at clinical high risk of psychosis, to see how many of them actually developed psychosis over the follow-up period. There also is discussion of a clinical trial of citicoline for cocaine dependence in bipolar I disorder. Articles may be viewed online at ajp.psychiatryonline.org.

This audio program features a discussion of differential diagnosis of frontotemporal dementia, autoimmune encephalitis in postpartum psychosis, the role of oxytocin in borderline personality disorder, neural correlates of error processing in young people exposed to severe childhood abuse, light therapy versus cognitive-behavioral therapy for seasonal affective disorder, and cognitive enhancement treatment for people with mental illness who do not respond to supported employment. Articles may be viewed online at ajp.psychiatryonline.org.

This audio program includes a discussion of the role of the psychiatrist in the collaborative care model, pharmacological management of Lewy body dementia, the relationship of depression subtype to antidepressant response, amygdala activity at rest in paranoid individuals with schizophrenia, and the use of clonidine in opioid abstinence to prolong abstinence and decouple stress from craving in daily life. Articles can be viewed online at ajp.psychiatryonline.org.

This audio program explores the diagnostic precursors of bipolar disorder in offspring of bipolar parents, as well as a study examining the intergenerational transmission of anxiety, by looking at the children of twins, and another focusing on separation anxiety disorder in children and adults. Various diagnoses are characterized by impaired response inhibition, and a study is presented of how it relates to neural activation in adolescents with ADHD. Irritability also is a common phenotype, and a longitudinal study tracked the stability of genetic and environmental influences on irritability from childhood to young adulthood. Articles can be viewed online at ajp.psychiatryonline.org.

This audio program features a discussion on a pair of research articles on teenage drinking and on a review article on cognitive-behavioral therapy for anxiety disorders in adolescents. There also is discussion regarding psychiatric care during hepatitis C treatment with direct-acting antivirals, the effects of clozapine on working memory, and the combination of citalopram and methylphenidate for geriatric depression. Articles can be viewed online at ajp.psychiatryonline.org.

This audio program presents a discussion of diagnostic and clinical challenges of narcissistic personality disorder and of two clinical trials of psychotherapy. One examined interpersonal psychotherapy for PTSD, and the other tested the use of brief cognitive-behavioral therapy to reduce suicide attempts in military personnel with a previous history. An additional article compared the effects of different antidepressants on depressed women and looked at outcomes in the women's children, while another study examined whether the neuroanatomical aspects of autism spectrum disorder lie on a continuum in the general population. Articles can be viewed online at ajp.psychiatryonline.org.

This audio program includes a discussion of a study that used an algorithm to search electronic health records for clinical information relevant to the Research Domain Criteria; an article on predicting the transition from mild cognitive impairment to dementia; a trial on reducing reactivity to alcohol cues in patients with alcohol dependence; a study of the relationship between C-reactive protein and symptoms of PTSD; a trial examining the influences of health coaching for overweight persons with serious mental illness; and an intriguing short essay about correspondence between Charles Darwin and the head gardener at an English mental institution. Articles can be viewed online at ajp.psychiatryonline.org.

This audio program includes a discussion of adjustment disorder in a health care worker with Ebola, a case of psychotic symptoms that improved with a gluten-free diet, medication prescribing for first-episode schizophrenia, outcomes for young people at ultra-high risk for psychosis who do not transition to psychotic disorders, possible mechanisms in perimenopausal depression, and change during adolescence in reactivity of the amygdala in relation to stressful life events and family history of depression. Articles can be viewed online at ajp.psychiatryonline.org.

This audio program includes a study of postpartum psychosis and mania, a home-visiting intervention for pregnant teenage American Indian mothers, brain patterns underlying learning deficits in autism spectrum disorders, the clusters of genetic variants and clinical features of schizophrenia, the Affordable Care Act and its expansion of insurance for young adults. Articles can be viewed online at ajp.psychiatryonline.org.

This audio program includes a discussion of hypercalcemia and hyperparathyroidism during lithium therapy. It also examines ECT for treatment-resistant bipolar depression and for clozapine-resistant schizophrenia; a weight loss intervention for individuals taking antipsychotic medications; an intervention for kindergartners with chronic conduct problems; a clinical trial offering depression care in OB-GYN clinics; and treatment response related to insurance. Articles can be viewed online at ajp.psychiatryonline.org.

This audio program includes a discussion of mercury poisoning and its neuropsychiatric presentations and presents a large study that used a new approach to testing the effect of antidepressants on heart rate. Several articles are about biomarkers of psychiatric illness: one identified a combined epigenetic and genetic biomarker for suicide, and another found that a measure of inflammation in depressed patients predicted the outcome of treatment with escitalopram and nortriptyline. Finally, a commentary on biomarkers considers how biological tests can be incorporated into psychiatric diagnostic criteria. Articles can be viewed online at www.ajp.psychiatryonline.org.

This audio program explores pulmonary embolism in psychiatric patients, a trial of smoking cessation combining varenicline and bupropion, a trial comparing quetiapine with placebo for treatment of borderline personality disorder, a study of positive traits in co-twins of patients with bipolar disorder, a study evaluating the genetic and environmental contributions to familial recurrence of autism spectrum disorder, and a long-term study of the effectiveness of supported employment for persons with severe mental illness. Articles can be viewed online at www.ajp.psychiatryonline.org.

This audio program explores relapse prevention in pediatric depression and the risk of mania or hypomania for patients with bipolar depression taking an antidepressant without a mood stabilizer. The series on global mental health describes a man in Cambodia with seizures, anorexia, and depression. The issue covers adverse neuropsychiatric effects of glucocorticoid medications, the patient-therapist relationship in psychotherapy, and the outcomes of psychodynamic therapy and CBT in social anxiety disorder. Articles can be viewed online at www.ajp.psychiatryonline.org.

This audio program presents diagnostic and treatment aspects of disruptive mood dysregulation disorder, predictors of long-term outcome in youths with bipolar disorder, reading ability and elements of impulsivity related to aggression in schizophrenia, a global health review of a woman in Uganda with HIV and major depression, and the connection between schizophrenia and maternal levels of C-reactive protein. Articles can be viewed online at www.ajp.psychiatryonline.org.

This audio program presents a case of delirium with manic symptoms in a patient with end-stage COPD, a clinical vignette about a chronically depressed woman in Iran, low dopamine transmission in the prefrontal cortex of people with alcoholism, a test of mindfulness training as a way to increase resilience in Marines before deployment, the influences of maternal and paternal PTSD on epigenetic regulation of the glucocorticoid receptor gene in the offspring of Holocaust survivors, and the ties between the unexpected death of a loved one and psychiatric disorders across the life span. Articles can be viewed online at www.ajp.psychiatryonline.org.

This audio program discusses a new tool for screening military veterans to evaluate the risk of violence. One article reviews the care of pregnant women with ADHD, and another one reports on outcomes after in-utero exposure to lithium. Also discussed is the treatment of separation, generalized, and social anxiety disorders in children and adolescents, and two longitudinal studies shed light on the continuity of preschool depression and on adult health and functioning in people who were bullied as children. Articles can be viewed online at www.ajp.psychiatryonline.org.

This audio program discusses DSM-5 classification of anxiety and related disorders, antipsychotic use in breast cancer patients, and adult outcomes of disruptive mood dysregulation disorder. Treatment trials for a parental intervention aimed at preventing antisocial personality and family-focused treatment plus medication for adolescents with bipolar disorder are also examined. The issue also looks at Internet-delivered treatment for substance abuse, virtual reality therapy for PTSD in conjunction with either D-cycloserine or alprazolam, and treatment with a synthetic neuro-active steroid via aerosol nasal spray for women with social anxiety disorder. Articles can be viewed online at www.ajp.psychiatryonline.org.

This audio program begins with a new section, Perspectives in Global Mental Health, featuring cultural aspects of depression and ideas for global dissemination of psychological treatments. The issue also examines psychological interventions for psychosis, cognitive training, dietary coaching for elderly persons with subsyndromal depressive symptoms, psychiatric symptoms as risk factors for mild cognitive impairment, and how brain development relates to depression onset. Articles can be viewed online at www.ajp.psychiatryonline.org.

This audio program offers a commentary on the Research Domain Criteria project by the Director of NIMH. In addition, it reviews liver injury due to antidepressants, head injury as a risk factor for psychiatric disorders, whether women and men differ in the etiology of depression, the effect of cannabis on working memory in adolescent monkeys, whether a genetic polymorphism affected topiramate's efficacy for reducing alcohol consumption, and a clinical trial of computer-assisted cognitive-behavioral therapy for cocaine-dependent individuals maintained with methadone. Articles can be viewed online at www.ajp.psychiatryonline.org.

This audio program examines lurasidone treatment of bipolar depression, both as monotherapy and as an adjunct; psychotherapy for bipolar depression related to comorbid anxiety disorders; a computerized method for rating anxiety; genetic, family, and community risk factors for drug abuse; the risk of autoimmune diseases in individuals with a personal or family history of schizophrenia or related psychosis; and how memory is affected by knowing whether one has a gene variant that increases the risk for Alzheimer's disease. Articles can be viewed online at www.ajp.psychiatryonline.org.

This audio program examines the risk of upper gastrointestinal bleeding with short-term use of SSRIs and schizophrenia complicated by hepatitis C and hepatic encephalopathy. It also reports results from a study in which neuropsychological functioning was tracked from childhood to age 38, a study comparing psychoanalytic psychotherapy and CBT for bulimia nervosa, a review of the relation of childhood separation anxiety to adult anxiety disorders, and a review comparing approaches to refractory social anxiety disorder. Articles can be viewed online at www.ajp.psychiatryonline.org.